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Methoxetine MXE is a drug described as dissociative and it is synthetically made. It is often known as mexxy or MXE as well. It has similar results to ketamine but lasts longer and is stronger, although many of the long and short term effects of it are not yet known.


Buy Methoxetamine Online  also abbreviated as MXE,Buy Methoxetamine (MXE) Powder Online is a dissociative hallucinogen that has been sold as a designer drug.It differs from many dissociatives such as ketamine and phencyclidine (PCP) that were developed as pharmaceutical drugs for use as general anesthetics in that it was designed for grey market distribution Buy Methoxetamine Online .
MXE is an arylcyclohexylamine.It acts mainly as a receptor antagonist, similarly to other arylcyclohexylamines like ketamine and other research chemicals.Buy Methoxetamine (MXE) Powder Online.MXE is reported to have a similar effect to ketamine.It was often believed to possess opioid properties due to its structural similarity to 3-HO-PCP,but this assumption is not supported by data, which shows insignificant affinity for the µ-opioid receptor by the compound.Recreational use of MXE Buy Methoxetamine (MXE) Powder Online has been associated with hospitalizations from high and/or combined consumption in the US and UK.Acute reversible cerebellar toxicity has been documented in three cases of hospital admission due to MXE overdose, lasting for between one and four days after exposure.MXE was designed in part in an attempt to avoid the urotoxicity associated with ketamine abuse; it was thought the compound’s increased potency and reduced dose would limit the accumulation of urotoxic metabolites in the bladder.Like ketamine, MXE has been found to produce bladder inflammation and fibrosis after high dose, chronic administration in mice (although the dosages used were quite large).Reports of urotoxicity in humans have yet to appear in the medical literature.MXE acts mainly as a selective and high-affinity NMDA receptor antagonist, specifically of the dizocilpine (MK-801) site (Ki = 257 nM).It produces ketamine-like effects.In addition to antagonism of the NMDA receptor, MXE has been found to act as a serotonin reuptake inhibitor (Ki = 479 nM; IC50 = 2,400 nM).Conversely, it shows little or no effect on the reuptake of dopamine and norepinephrine (Ki and IC50 > 10,000 nM).Nonetheless, MXE has been found to activate dopaminergic neurotransmission, including in the mesolimbic reward pathway.


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