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Methadone

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Description

                                    Methadone

Buy Methadone online , its a synthetic diphenylheptanonylamine opioid that has similar analgesic activity and potency as morphine when administer parenterally. However, unlike morphine, it reliably retains its effectiveness when given orally, and tolerance and physical dependency develop slowly. Although methadone is prescribe to relieve chronic pain, its primary medical application is the detoxification and/or maintenance treatment of narcotic or heroin addiction.

Buy Methadone online, The abuse potential of methadone is comparable to that of morphine due to its resembling pharmacological activity. Methadone is available in tablets and as a solution for parenteral injection. It is readily absorb from the gastrointestinal tract when ingest, and metabolised extensively in the liver. Initial N-demethylation results in normethadone, which rapidly undergoes cyclization follow by dehydration to form the 2-ethylidene-1, 5-dimethyl-3, 3-diphenylpyrrolidine, commonly known as EDDP. Further N-demethylation yields a secondary metabolite, the 2-ethyl-5-methyl-3, 3-diphenyl-1-pyrroline (EMDP). The metabolites are secret in urine or bile along with unchange drug.

DOSAGE AND INDICATION

Dosage for detoxification of opioid addiction
Adult dosage (ages 18–64 years)

Typical starting dosage: 20–30 mg.
Dosage increases: After waiting two to four hours, your doctor may give you an extra 5–10 mg.
The Typical dosage: For short-term detoxification, the typical dosage is 20 mg taken two times per day for two to three days. Your doctor will slowly decrease your dosage and watch you closely.
Maximum dosage: On the first day, you shouldn’t take more than 40 mg total.

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